Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease

• Phase: Phase 3

Details

• Lead Sponsor: OraPharma
• Treatments: Minocycline

Criteria

Inclusion Criteria:

• Generalized moderate to advanced chronic periodontitis, five sites with probing depths of >5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants

Exclusion Criteria:

• Allergy to tetracycline

• Subjects with aggressive periodontitis

• Acute necrotizing ulcerative gingivitis, or gross decay

• Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc)

• Individuals requiring prophylactic antibiotics

• Any periodontal therapy within the previous 3 months (excluding maintenance therapy)

• Systemic or local antibiotic therapy within three months