Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis.
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
In conventional treatment for non-complicated bacterial cystitis, 3-day oral antibiotics
could achieve good cure rate. However, severe lower urinary tract symptoms were most
bothersome and only could be partially relieved by NSAID, detrusor muscle relaxants, minor
tranquilizer or pyridium. Some medication associated side effects were complained while
receiving adjuvant medication treatment, including gastro-intestinal discomfort, dry mouth,
blurred vision, lethargy, or allergic reactions. The irritative bladder symptoms from bladder
inflammation had great impact on the quality of life and well tolerable adjuvant therapy
would have clinical benefit to reduce the discomfort from the bladder.
In the past years, cranberry juice or its extract has been proven to have protective effect
on urothelium to prevent further bacterial ascending infection. The commercial cranberry
extract tablets have good tolerability and showed good effect on symptoms reliving and
infection protection on several clinical observation. In acute bladder infection, we could
expect the bioactive components in cranberry could reduce the virulence of pathogens and
assist to eradicate pathogens and to stable the urothelium. In literature review, only little
works focusing on the symptoms relief in acute cystitis patients. To clarify the clinical
benefit on lower urinary symptoms relieving, we attempt to conduct a randomized double-blind
placebo-controlled trial to evaluate the effect of a compound cranberry extract tablet as an
adjunctive modality in treating acute uncomplicated bacterial cystitis in otherwise healthy
female patients.