Effect of Aldosterone Blockade on Arterial Compliance

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study investigated the long-term (12 months) effect of spironolactone treatment on glucose homeostasis, metabolic parameters and vascular properties.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wolfson Medical Center
• Treatments: Spironolactone

Criteria

Inclusion Criteria:

1. patients with type 2 diabetes mellitus

Exclusion Criteria:

1. history of unstable angina, myocardial infarction (MI), cerebrovascular accident (CVA)

2. major surgery within the six months preceding entrance to the study

3. unbalanced endocrine disease

4. any disease that might affect absorption of medications

5. plasma creatinine >2.5 mg/dl

6. elevation of liver enzymes to more that twice the upper normal limit

7. plasma potassium levels >5.5 mg/dl