Effect of Aldosterone on Energy Starvation in Heart Failure
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
We plan to study the concept of "energy starvation" in heart failure by evaluation of
patients with nonischemic dilated cardiomyopathy (NIDCM) (heart failure with reduced heart
pump function due to causes other than heart attack). We will use a combination of positron
emission tomography and magnetic resonance imaging to study metabolism, anatomy, function,
blood flow and efficiency, before and after 6 months' treatment with the drug spironolactone
which blocks the deleterious effects of the hormone aldosterone on the myocardium (heart
muscle).
Phase:
Phase 4
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center