Effect of Alphagan and Xalatan Eye Drops on Corneal Temperature

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

It is already known that the local treatment with Alphagan eye drops (a drug commonly used by glaucoma patients) reduces ocular blood flow. In-vitro studies suggest that the vasoconstrictive effect of Alphagan is more pronounced when this drug is combined with a prostaglandin analogue (eg. Xalatan eye drops). The investigators also question whether this effect is more pronounced in subjects suffering from a primary vascular dysregulation (PVD). To test for the effect of these drugs on PVD and non-PVD subjects the investigators will take measurements of corneal temperature as surrogate for ocular blood flow.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Brimonidine Tartrate; Latanoprost; Ophthalmic Solutions

Criteria

Inclusion Criteria:

• healthy

• age 18-48 years

• normal findings on ophthalmological examination

Exclusion Criteria:

• history of ocular or systemic disease

• chronic or current systemic or topical medication

• drug or alcohol abuse

• art. hypertension