Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension

• Status: Completed
• Trial end date: 2006-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Anhui Medical University
• Collaborators: Peking University First Hospital; The University of Science and Technology of China
• Treatments: Amlodipine; Prazosin; Terazosin

Criteria

Inclusion Criteria:

1. Men 50 years or older

2. with LUTS [defined as International Prostate Symptom Score (IPSS) >= 10].

3. Stage 1 or 2 essential hypertension (SBP >= 140 mm Hg and < 180 mm Hg and/or DBP >= 90 mm Hg and < 110 mm Hg)

Exclusion Criteria:

1. A history of postural hypotension

2. Secondary hypertension

3. Prostate cancer

4. Prostate surgery or other intervention

5. Use of any agents to influence the LUTS symptoms in the last 4 weeks

6. Other severe diseases