Overview

Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery

Status:
Completed

Trial end date:
2017-08-10

Target enrollment:
0

Participant gender:
All

Summary

CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression. Propofol and volatile anesthetics were related to immune reaction. However, the effect of propofol and sevoflurane on the change of CD39 and CD73 after CPB was not evaluated in previous studies. The authors hypothesized that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing CPB. Therefore, the present study determined the effect of propofol and sevoflurane on CD39 and CD73 during and after CPB.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Konkuk University Medical Center

Treatments:

Propofol
Sevoflurane

Criteria

Inclusion Criteria:

1. patients scheduled to undergo elective cardiac surgery

2. signed written informed consent agreements

Exclusion Criteria:

1. Emergency operation that could not obtain pre-CPB1 sample

2. Patients who have infectious factor before operation

3. Patients who have immunosuppressive agent for underlying disease before operation

4. Patients who have history of cancer previously

5. Patients who are younger than 19 years old