Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
Status:
Completed
Trial end date:
2017-08-10
Target enrollment:
Participant gender:
Summary
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune
related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during
cardiac surgery, and induce immunosuppression. Propofol and volatile anesthetics were related
to immune reaction. However, the effect of propofol and sevoflurane on the change of CD39 and
CD73 after CPB was not evaluated in previous studies.
The authors hypothesized that the expression of CD39 and CD73 would differ between propofol-
and volatile anaesthetic-based anaesthesia in patients undergoing CPB. Therefore, the present
study determined the effect of propofol and sevoflurane on CD39 and CD73 during and after
CPB.