Effect of Anesthetics on Cardiac Biomarkers in Mitral and Aortic Valve Replacement/Plasty

• Status: Completed
• Trial end date: 2023-01-09
• Target enrollment: 0
• Participant gender: All

Summary

Abstract Cardiac troponin is one of the biomarkers of the heart, and its high level correlates with a high risk of damage to cardiomyocytes.

Objective: To determine the effect of anesthetics on cardiac enzymes during mitral and aortic valve replacement in adults.

methods. Single-center prospective randomized controlled clinical study. A total of 255 patients were assigned randomly into three groups according to the type of anesthesia: the first group of 85 patients with propofol, the second group with sevoflurane - 85 patients, and the last - 85 patients were with isoflurane.

Cardiac troponin I levels were calculated in ng/mL using the i-CHROMAII portable fluorescent analyzer manufactured by BoditechMedInc. (South Korea). Normal range: <0.4 ng/mL. Cardiac index (CI=CO/body surface area), oxygen consumption (VO2 = Cardiac index (CI)*AVD or VO2 = CO × (CaO2 - CvO2) ~ CO × Hb × 1.34 × (SaO2 - SvO2) / 100) were determined before induction into anesthesia.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Astana Medical University
• Treatments: Isoflurane; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• The age is between 50-65 years old;

• Mitral and aortic valve insufficiency grade 3-4;

• Participants of both sexes will be included in the study;

• Planned surgical interventions;

• Signed informed consent.

Exclusion Criteria:

• pregnancy (risk to the baby and mother)

• hypertensive disease

• coronary artery disease;

• current unstable angina pectoris;

• preoperative hemodynamic instability, defined as the use of vasopressors;