Effect of Anti-histamine in Prevention Systolic Hypotension After Protamine
Status:
Completed
Trial end date:
2019-03-31
Target enrollment:
Participant gender:
Summary
Protamine remains the anticoagulant of choice for cardiopulmonary bypass (CPB). The process
of protamine neutralization of heparin came with the side effects sometimes; it can be life
threatening or fetal reaction. The adverse cardiopulmonary response of protamine has been
observed during entire history of clinical cardiac surgery. The true mechanism reaction is
difficult to defined and the complexity of the clinical situation The classification of
protamine reaction has been divided in to main 3 types (transient systemic hypotension
secondary to rapid administration, anaphylactic and anaphylactoid reaction and catastrophic
pulmonary vasoconstriction.
The reaction from pharmacologic histamine release is the most common type of reaction.
Protamine was believed to induce hypotension by this mechanism, and it was demonstrated to
release histamine by degranulation of isolated mast cells From the hypothesis that the
systemic hypotension cause by the released of histamine. The investigators will measure the
serum tryptase which is the enzyme that released from degranulation of human mast cell.
Comparing the serum tryptase level of the patient at baseline, 30 min and 60 min after
protamine was given.
There for the hypothesis of this study is administrating of H1 and H2 blocker helps attenuate
the drop in MAP after protamine is given.