Effect of Antibacterial Mouthwash on Muscle Function in Healthy Young Men and Women

• Status: Active, not recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effects of antibacterial mouthwash on muscle speed and power in healthy young men and women. We have previously demonstrated that drinking beetroot juice, a source of dietary nitrate and therefore nitric oxide, increases muscle function in this population. Antibacterial mouthwash has been shown to interfere with the conversion of dietary nitrate to nitric oxide. We therefore hypothesize that it will diminish nitric oxide bioavailability and inhibit muscle contractility.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indiana University
• Treatments: Anti-Bacterial Agents; Benzocaine

Criteria

Inclusion:

• Men and Women age 18-30 years old

• No current use of mouthwash

Exclusion:

• Men and Women <18 or 30> y of age

• Unable to provide informed consent

• Current users of mouthwash

• Current antibiotic use

• Current smokers

• Currently pregnant or lactating

• Stage II hypertension (resting blood pressure >140/>90)

An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q) indicating that the subject is not physically ready for exercise without a medical exam. These exclusions include the following:

• If participant's doctor has ever said that he/she has a heart condition and that he/she should only do physical activity recommended by a doctor

• Pain in chest when doing physical activity

• In past month, chest pain when not doing physical activity

• If participant has ever lost balance because of dizziness or has ever lost consciousness

• Bone or joint problem that could be made worse by change in physical activity

• Currently on prescribed drugs for blood pressure or heart condition.

• If the participant knows of any other reason why he/she should not do physical activity.