The purpose of this study is to determine whether different types of antidepressant medicines
relieve back pain that has lasted at least six months on a daily basis. Study participants
will be assigned to treatment with either a antidepressant acting on the serotonin system in
the brain (fluoxetine), one acting on the noradrenaline system (desipramine, or to a control
medication not expected to relieve pain (benztropine). Each participant will be seen at least
nine times during their 12 weeks on medication. This is a phase 2/3, outpatient study.
Phase:
Phase 2
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development