Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study will evaluate the effect of antidepressants on sex hormone levels in women and if the potential changes in sex hormone levels are related to sexual side effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Antidepressive Agents; Bupropion; Fluoxetine; Hormones; Serotonin; Serotonin Uptake Inhibitors

Criteria

Inclusion Criteria:

• Regular menstrual cycles that are 25 to 35 days in length during the 1 year prior to study entry

• Willing to engage in sexual activity, alone or with a partner, at least weekly for the duration of the study

• Willing to use effective birth control (e.g., condom, diaphragm with spermicide, tubal ligation, nonhormonal intrauterine device,, partner with vasectomy) for the duration of the study

Exclusion Criteria:

• Medical illness that may contribute to sexual dysfunction or affect steroid hormone levels

• Body mass index (BMI) greater than 30

• Elevated testosterone at screening

• History of seizure disorder

• Consumes more than 10 alcoholic beverages per week