Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea
Status:
Completed
Trial end date:
2017-02-14
Target enrollment:
Participant gender:
Summary
The investigators investigated diastolic function among patients with obstructive sleep apnea
(OSA) and hypertension stage I. In this randomized controlled trial, participants were
randomly allocated to one of two groups: chlorthalidone associated with amiloride or
amlodipine. Randomization was carried out prior to the start of the trial by an
epidemiologist out of clinic and the randomization list was stratified by gender and severity
of OSA. The research team and participants were blinded to the randomization list and
allocation concealment was implemented. This trial aimed to detect changes in the
echocardiography parameters with the drug treatment (higher in the intervention than in the
placebo group). The investigators also assess change in daytime sleepiness among participants
who already have been diagnosed with OSA.