Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum

• Status: Completed
• Trial end date: 2001-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Treatment of uncomplicated P.falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a marked increase in the density of gametocytes. To determine whether treatment with SP enhances gametocyte carriage, we randomized asymptomatic carriers of P.falciparum to receive SP alone, SP with a single dose of artesunate, or placebo, and followed them for 56 days to record gametocyte presence and density.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: London School of Hygiene and Tropical Medicine
• Collaborator: Medical Research Council Unit, The Gambia
• Treatments: Antimalarials; Artesunate; Fanasil, pyrimethamine drug combination; Pyrimethamine; Sulfadoxine

Criteria

Inclusion Criteria:

• P.falciparum parasitaemia above 20/uL

• Resident in one of the four study villages

Exclusion Criteria:

• Fever

• Any other sign of clinical malaria

• Pregnancy

• Weight <5kg

• History of hypersensitivity to any of the study drugs

• Treatment with any of the study drugs in the last 4 weeks