Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum
Status:
Completed
Trial end date:
2001-12-01
Target enrollment:
Participant gender:
Summary
Treatment of uncomplicated P.falciparum malaria with sulfadoxine-pyrimethamine (SP) is
followed by a marked increase in the density of gametocytes. To determine whether treatment
with SP enhances gametocyte carriage, we randomized asymptomatic carriers of P.falciparum to
receive SP alone, SP with a single dose of artesunate, or placebo, and followed them for 56
days to record gametocyte presence and density.
Phase:
Phase 3
Details
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborator:
Medical Research Council Unit, The Gambia
Treatments:
Antimalarials Artesunate Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine