Effect of Apelin on Insulin Sensitivity: Proof of Concept in Healthy Volunteers
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
The (PYR1)-apelin-13 is an endogenous peptide discovered relatively recently (1998). The
apelin and its receptor, which is named apj, are expressed in many tissues including
sensitive to the action of insulin, such as skeletal muscle, adipose tissue and heart tissue.
Recent work by the team of Prof. P.Valet (INSERM U1048, Toulouse) opened a new field of
investigation, demonstrating for the first time in mouse models that apelin exerts a
glucose-regulating in vivo action. The investigators propose a translational clinical
research project whose goal is to provide the proof of concept of the favorable influence of
apelin on insulin sensitivity in humans.