Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System

• Status: Recruiting
• Trial end date: 2024-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to explore whether administration of preservative free artificial tears will decrease the level of detectable radioiodine in the tears and nasolacrimal duct system of patients undergoing radioiodine therapy for thyroid carcinoma and thus decrease the risk of developing radioactive iodine associated nasolacrimal duct obstruction.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt-Ingram Cancer Center
• Treatments: Lubricant Eye Drops

Criteria

Inclusion Criteria:

• Radio-iodine therapy for thyroid cancer

• Radioiodine therapy ≥150mCi

• Patient wears soft contacts on both eyes

Exclusion Criteria:

• Use of eye drops, other than artificial tears

• History of ocular/lacrimal gland trauma

• History of lacrimal drainage disease: canaliculitis, dacryocystitis

• Prior radiotherapy

• Current or prior use of chemotherapy drugs (i.e. 5-fluorouracil, docetaxel)

• Medical conditions that predispose to NLD stenosis

• Sarcoid

• Granulomatosis with polyangiitis

• Chronic lymphocytic leukemia