Effect of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery
Status:
Unknown status
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
Postoperative pulmonary complications(PPCs) including, but not limited to ,hypoxemia,
pneumonia, ventilator-induced lung injury, and acute respiratory distress syndrome
(ARDS),atelectasis,pleural effusion .PPCs may result in increased resources utilization,
delayed mobilization, prolonged need of supplemental oxygen or mechanical ventilation,and a
longer hospital stay.postoperative pulmonary complications are common after cardiac surgery,
often increasing postoperative morbidity and mortality.The extracorporeal
circulation,increased oxygen concentration inhaled and the development of massive atelectasis
after open-chest surgery commonly activate lung inflammation, amplifying the harm Injury of
pulmonary .Currently, plenty of interventions have been studied to prevent PPCs after
surgery. Most of the recent research has focused on physical therapy such as lung-protective
modes during intraoperative mechanical ventilation, Alveolar Recruitment, and respiratory
muscle training.These therapies have a certain effect, but still not satisfactory.Ascorbic
acid is an important cofactor in multiple enzymatic reactions where its main function is as a
reducing agent.Studies have shown that ascorbic acid can reduce both ischemia-reperfusion
injury and oxidative stress. Unfortunately, no studies examined whether Ascorbic acid can
reduce PPCs.