Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesize that
1. an acute treatment of low-dose aspirin will lead to a) decreased resting platelet
activation, platelet aggregation, and clotting potential, b) increased fibrinolytic
potential following fire fighting, c) no significant effect on endothelial function or
arterial stiffness versus the placebo condition.
2. chronic treatment with low-dose aspirin will lead to a) decreased resting and fire
fighting induced platelet activation, platelet aggregation, clotting potential, b)
increased fibrinolytic potential, and c) increased endothelial function and decreased
arterial stiffness in response to live fire fighting versus the placebo condition.
3. short-term fire fighting activity will result in: a) a reduction in arterial function
(reduced endothelial function, increased augmentation index and an attenuated arterial
stiffness response); b) a disruption in hemostasis that is characterized by an increase
in platelet number and function, an increased coagulatory potential and altered
fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic
inflammation, monokine chemoattractant protein, and matrix metalloproteinases.