Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia

• Status: Completed
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

Many studies have explored the effects of inhalation anesthetics, intravenous anesthetics, and muscle relaxants on spectral entropy, but most did not monitor the degree of neuromuscular block. In addition, they do not explore the effects of different degrees of neuromuscular blockade on spectral entropy under different concentrations of isoflurane inhalation. Therefore, the present study will evaluate different levels of MAC to quantify the isoflurane concentration, as well as different degrees of neuromuscular blockade

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Atracurium; Bromides; Rocuronium

Criteria

Inclusion Criteria:

1. Patients American Society of Anesthesiologists physical status (ASA) I to II.

2. Male patients (to avoid bias between gender).

3. Age between 20-50 years

Exclusion Criteria:

• a. Patients receiving any neuropsychiatric medications. b. Patients undergoing neurosurgical operation. c. Drug addiction. d. Body mass index (BMI) more than or equal to 40.