Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment
Status:
Not yet recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
Primary purpose: Evaluate the effect of azithromycin on failure proportion of severe chronic
periodontitis non-surgical treatment; failure characterized by the persistence of at least
one periodontal pocket> 5mm at 6 months
Secondary purpose:
- Evaluate the effect of azithromycin on the persistence of pathological periodontal
pockets > 5mm during non-surgical treatment of severe chronic periodontitis at 3 months
and 6 months
- Evaluate the effect of azithromycin on the changes of clinical signs, periopathogen
levels, expression of macrolides resistance genes, and expression of antimicrobial
peptides (PAMs) during treatment of severe chronic periodontitis at 3 months and 6
months
- Assess therapeutic observance and side effects of antibiotic treatment
- Assess at 3 and 6 months the potential interactions of local, bacterial (periopathogen
and resistance gene) clinical factors, and host defense (PAMs) with the effect of
azithromycin, on failure proportion of severe chronic periodontitis non-surgical
treatment