Effect of Azithromycin on Fatty Acids in CF

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In collaboration with Dr.Birgit Alteheld, Institute of Nutrional Sciences of the university of Bonn, Germany the following effect is explored: Effect of a 4 week therapy with AZT on synthesis of lipoproteins as well as Docosahexaen and other fatty acids in patients with Cystic Fibrosis (CF). Moreover proinflammatory cytokines in blood and sputum are of interest.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Childrens' Hospital (Zentrum für Kinderheilkunde des Universitätsklinikum Bonn)
• Collaborators: University Hospital, Frankfurt; University of Bonn
• Treatments: Azithromycin

Criteria

Inclusion Criteria:

• Delta 508 homozygous and regularly visiting the CF outpatient clinic Bonn

Exclusion Criteria:

• clinical or laboratory signs (CRP > 20 mg/L) of an exacerbation,

• treatment with systemic steroids 14 days preceeding this trial

• elevated liver function tests (> twice normal range)