Overview

Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients

Status:
Not yet recruiting

Trial end date:
2027-12-12

Target enrollment:
0

Participant gender:
All

Summary

To compare the direct effect of sodium acetate ringer injection or albumin on volume expansion in shock patients, and to provide reference for volume resuscitation strategy in shock patients

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Peking Union Medical College Hospital

Criteria

Inclusion Criteria:

1. Age ≥ 18 years old, gender unlimited

2. Shock requires volume resuscitation:

Insufficient tissue perfusion: wet and cold skin, decreased urine volume
(<0.5ml/kg/h), change of consciousness, blood lactate >2.0mmol/l or vasoactive drugs
are required to maintain map>65mmhg

3. Presence of volume reactivity: (under controlled ventilation) PPV ≥ 15% or passive leg
raising test (+) or (under controlled ventilation) IVC variability ≥ 18% or the
presence of volume reactivity as judged by clinicians

4. The patient has no obvious restlessness, RASS ≤ 0

5. The legal representative of the subject signs the informed consent form-

Exclusion Criteria:

1. Pregnant and lactating women

2. End stage patients

3. BMI ≤ 15 or BMI ≥ 50

4. Contraindication of indwelling central vein catheter and invasive arterial catheter

5. Patients in ECMO and / or IABP therapy

6. Hemorrhagic shock, blood products such as concentrated red blood cells, plasma and
platelets will be infused within 1 hour

7. Myocardial infarction, NYHA grade IV

8. Patients with hyperkalemia, hypercalcemia, hypermagnesemia and hypothyroidism

9. Allergic to compound sodium acetate ringer injection or albumin or with known side
effects

10. Other factors that may affect the monitoring and evaluation of relevant indicators