Overview
Effect of Benralizumab in Patients With Severe Nasal Polyps
Status:
Recruiting
Recruiting
Trial end date:
2020-07-01
2020-07-01
Target enrollment:
400
400
Participant gender:
All
All
Summary
This is a randomized placebo controlled trial to evaluate the effect of benralizumab on people with severe nasal polyps.Phase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Johns Hopkins University
Criteria
Inclusion Criteria:- Age 18-75
- Severe bilateral nasal polyps (score 5 out of 8)
- SNOT-22 score > 30
- At least 70% compliance with inhaled nasal steroid based on daily diary
- Minimum weight of 40kg
- Negative pregnancy test for documented post menopausal for women
Exclusion Criteria:
- Any sinus surgery within the past 6 months