Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure

• Status: Completed
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate the effect of the two different beta blockers metoprolol and carvedilol on endothelial function in patients with either type two diabetes or chronic heart failure.

Hypothesis: 1* Carvedilol compared to metoprolol has a favourable effect on endothelial function.

2* Carvedilol compared to metoprolol has a favourable effect on insulin stimulated endothelial function.

The study is conducted as an open parallel group study. Endothelial function and insulin stimulated endothelial function was evaluated before and after a two months treatment period with either of the two beta blockers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bispebjerg Hospital
• Collaborator: Danish Heart Foundation
• Treatments: Adrenergic beta-Antagonists; Carvedilol; Metoprolol

Criteria

Inclusion Criteria:

• Type 2 diabetes

• Chronic heart failure

Exclusion Criteria:

• For patients with type 2 diabetes:

• Vascular complications.

• For patients with chronic heart failure:

• Severe uncontrolled heart failure.

• Untreated severe hypertension, hypotension.

• Bradycardia.

• Known intolerance to beta blocker treatment.

• Pregnancy,