Effect of Beta-blocker on Cardioprotective Effect of Remote Ischemic Conditioning

• Status: Completed
• Trial end date: 2017-11-10
• Target enrollment: 0
• Participant gender: Male

Summary

Remote ischemic conditioning has been shown to protect myocardium from ischemia-reperfusion injury during cardiac intervention or cardiac surgery. However, effect of beta-blocker, commonly used cardiovascular medication in patients with cardiac diseases such as hypertension or angina pectoris, on cardioprotective role of remote ischemic conditioning has not been well documented. The purpose of the study is to investigate the effect of beta-blocker on remote ischemic conditioning in healthy volunteers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Adrenergic beta-Antagonists; Carvedilol

Criteria

Inclusion Criteria:

• Healthy male volunteer

• Not taking any medication

Exclusion Criteria:

• BMI < 18 kg/m2 or > 30 kg/m2

• Allergic history of any medication

• Baseline SBP > 150 mmHg or < 100 mmHg

• Baseline DBP > 100 mmHg or < 50 mmHg

• Strenuous exercise, excessive caffeine or alcohol, smoking 24 h prior to experiment

• Cannot undergoing remote ischemic conditioning for any reason

• Refuse to enroll