Effect of Bosentan on Exercise Capacity at High Altitude

• Status: Completed
• Trial end date: 2007-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude.

We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: VA Loma Linda Health Care System
• Collaborator: Actelion
• Treatments: Bosentan

Criteria

Inclusion Criteria:

• Normal healthy subjects aged 18 - 55 years

Exclusion Criteria:

• Pregnancy

• Heart, lung or liver disease

• Use of glyburide, cyclosporin A