Effect of Botox and Vibration on Bone in Children With Cerebral Palsy
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000
individuals in the U.S. An estimated 70-80% of these individuals have spasticity which
affects ambulation and requires management. Therefore, the treatment of spasticity is a
primary goal of interventions for children with CP. One treatment widely used to reduce
spasticity is Botox because of its ability to temporarily paralyze a muscle. However, no
studies have determined the effect of Botox treatment on bone in humans. Also, a low
magnitude vibration treatment has been shown to improve bone structure in the lower extremity
bones of children with CP. The aims of this study are: 1) to determine the effect of Botox
treatment in conjunction with a daily vibration treatment on bone mass and bone structure in
children with spastic CP, and 2) to identify the mechanism that underlies the effect of Botox
and vibration on bone.
Phase:
N/A
Details
Lead Sponsor:
University of Delaware
Collaborators:
Alfred I. duPont Hospital for Children Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Treatments:
abobotulinumtoxinA Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA