Effect of Botulinum Toxin Injection Into Upper Esophageal Sphincter in Patients With Medullary Infarction
Status:
Recruiting
Trial end date:
2024-12-12
Target enrollment:
Participant gender:
Summary
Dysphagia is an important complication in patients with medullary infarction, the incidence
rate is 57%-69%. Compared with other brain infarctions, the medulla oblongata involves
multiple swallowing-related nerve nuclei, and the possibility of brain remodeling after
injury is small. Dysphagia has become a prominent clinical problem in patients with medullary
infarction, which can lead to malnutrition, decrease the quality of life of patients and
affect the prognosis of the disease. Solving this clinical problem is particularly important
for patients with medullary infarction. The incidence of UES opening disorder in patients
with medullary infarction is as high as 80%, and the clinical problem of UES opening disorder
is enthusiastically studied at home and abroad. At present, the intervention measures include
balloon dilatation, surgical incision and botulinum toxin injection. Balloon dilatation is
easy to cause mucosal edema and damage, and cricopharyngeal myotomy often has complications
such as local infection, massive hemorrhage and local nerve injury. There is no significant
difference between the success rate of UES botulinum toxin injection and surgical incision.
Among the above measures, UES botulinum toxin injection has a good clinical application
prospect, but the drug dosage and injection method are still not unified in clinic. In
particular, how to accurately locate has become a hot topic in current research. On this
basis, this study uses ultrasound combined with balloon localization to inject UES botulinum
toxin and make clinical observation.
Phase:
N/A
Details
Lead Sponsor:
The First Affiliated Hospital of Zhengzhou University
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A