Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression

• Status: Completed
• Trial end date: 2006-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine the relationship between brain lesion severity, treatment response, and frontal lobe brain function in people with late-life depression (LLD).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Sertraline

Criteria

Inclusion Criteria:

• DSM-IV of major depressive disorder (MDD)

• Score of greater than 20 on the MADRS (score of greater than 17 for atypical depression)

• Score of greater than 20 on the Mini Mental State Examination (MMSE)

Exclusion Criteria:

• Any condition that may make having an MRI medically inadvisable

• Any severe or unstable medical conditions

• Any known primary neurological disorders, including history of stroke

• Any other simultaneous Axis I disorder

• History of substance or alcohol abuse disorder within 6 months prior to study entry

• Currently at risk for suicide

• History of failed prior adequate trials of two antidepressants for the current depressive episode

• History of failed prior adequate trial of sertraline

• Current use of any other psychoactive medications (medication washout will be required)