Overview

Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars

Status:
Not yet recruiting
Trial end date:
2023-02-10
Target enrollment:
0
Participant gender:
All
Summary
the aim of the study is to compare the effect of bromelain vs calcium hydroxide as intracanal medication on intensity of pain and bacterial load in necrotic single lower premolars
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Cairo University
Treatments:
Calcium
Criteria
Inclusion Criteria:

1. Patients who are free from any physical or mental handicapping condition with no
underlying systemic disease (ASA I or II) .

2. Age between 25-50 years old.

3. Males & Females.

4. Patients who can understand pain scale and can sign the informed consent.

5. Mandibular Single rooted premolars, having single root canal:

- Diagnosed clinically with pulp necrosis.

- Absence of spontaneous pulpal pain.

- Positive pain on percussion denoting apical periodontitis.

- Slight widening in the periodontal membrane space with or without periapical
radiolucency radiographically.

- Normal occlusal contact with opposing teeth

Exclusion Criteria:

- Medically compromised patients: Pain levels and healing following treatment would be
compromised as these patients have shown higher incidence of pain and lower healing
rate.

- Pregnant women: Avoid radiation exposure, anesthesia, and medication.

- If antibiotics have been administrated by the patient during the past 12 hours
preoperatively might alter their pain perception.

- Patients reporting bruxism or clenching: Avoid further pressure on an already inflamed
tooth inducing subsequent irritation and inflammation.

- Teeth that shows association with acute periapical abscess and swelling: Need special
treatment steps which could involve additional visits with incision and drainage.
Also, it could influence initiation and progression of postoperative pain.

- Greater than grade I mobility or pocket depth greater than 5mm. Need special surgical
and/or periodontal therapy.

- No restorability: Hopeless tooth.

- Immature teeth.

- Radiographic evidence of external or internal root resorption.