Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia

• Status: Completed
• Trial end date: 2006-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Many individuals with schizophrenia smoke cigarettes but little is known about the factors that control smoking in people with schizophrenia. The purpose of this trial is to evaluate how bupropion, an antidepressant medication, affects smoking behaviors in individuals with schizophrenia who smoke.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Bupropion; Nicotine

Criteria

Inclusion Criteria:

• Diagnosed with schizophrenia or schizo-affective disorder

• Smokes between 20 and 50 cigarettes per day

• Moderate to high nicotine dependence score

• Interest in quitting smoking

Exclusion Criteria:

• Currently trying to quit smoking

• Seizure disorder or lowered seizure threshold due to anorexia, bulimia, head trauma, diabetes with insulin, or hypoglycemics

• Alcohol or drug use disorders

• Requires certain medications

• Pregnant or breastfeeding