Effect of Buscopan on Gastrointestinal Imaging Quality With Probe-based Confocal Laser Endomicroscopy
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Gastrointestinal cancer has developed into a serious health problem in China. 80%-90%
patients were detected at middle and later stage. The five-year survival rate for advanced
cancer patients is less than 10%. The main reason of the bad clinical diagnosis and treatment
is that the present technical method is difficult to achieve early diagnosis. Endoscopy with
biopsy is still the main method for confirming gastrointestinal cancer. But it is limited to
identify early tumors and it leads to the low diagnostic rate of early tumors and the poor
overall therapeutic effect.
Confocal laser endoscopy (CLE) can obtain pathologic information of lesion in real time and
improve the diagnostic rate of early tumors. Probe-based confocal laser endomicroscopy(pCLE)
is a new technology recently. Since its laser probe is applicable to all conventional
endoscopes, pCLE greatly increased its clinical application. However, gastrointestinal
motility has greatly influence on pCLE imaging quality and inspection effect owing to the
poor stability of the small probe manipulation. Scopolamine (654-2, in China) is clinically
used to inhibit bowel peristalsis, but its effect is still not ideal and its side effects are
common.