Effect of CAFfeine on Cognition in Alzheimer's Disease
Status:
Not yet recruiting
Trial end date:
2024-11-01
Target enrollment:
Participant gender:
Summary
Sporadic Alzheimer's disease is a multifactorial illness arising a major medico-economic
stakes for our aging societies. There is currently no curative treatment available.
Coffee is a complex beverage with psychostimulant properties whose main effective element,
caffeine, has a pleiotropic effect on the central nervous system. Caffeine pharmacological
properties enable its use like an Alzheimer's disease symptomatic treatment. Its supposed
benefits mustn't obscure anxiety and insomnia caffeine effect at large dose, which
Alzheimer's patients might be more vulnerable.
The main study objective is to evaluate placebo-controlled caffeine efficacy (30 treatments
weeks) on cognitive decline in Alzheimer's disease dementia at beginning to moderate stage
(MMSE 16-24).