Effect of CPP-ACP Paste on Dental Caries in Primary Teeth

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if adding daily application of CPP-ACP containing paste for one year is superior to regular fluoride tooth brushing in preventing dental caries in high caries risk Thai preschool children.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Thammasat University
• Collaborators: Fogarty International Center of the National Institute of Health; John E. Fogarty International Center (FIC)
• Treatments: 6-chloro-2-(1-piperazinyl)pyrazine; Caseins

Criteria

Inclusion Criteria:

• Healthy Thai boys and girl aged between 2 1/2 - 3 1/2

• Normal development of dentition

• Diagnosed as high caries risk by using the Caries-risk Assessment Tool(CAT)

Exclusion Criteria:

• Chronic use of medications or antibiotics.

• Lack of cooperation in oral examination

• Milk protein allergy and/or benzoate preservatives

• Presence at baseline oral soft tissue lesion and enamel hypoplasia.

• Receive fluoride supplement and professional topical fluoride application at least three months before the beginning of study or during study period