Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary Dysplasia

• Status: Recruiting
• Trial end date: 2025-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate the effectiveness of caffeine versus probiotics supplementation as adjuvant therapy for preterm neonates with Bronchopulmonary dysplasia (BPD).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Caffeine

Criteria

Inclusion Criteria:

• Male and female preterm neonates less than 37 weeks gestational age.

• Suffering from Bronchopulmonary dysplasia (BPD) diagnosed as follow:

• History: Preterm infant with persistence oxygen dependency up to 28 days of life.

• Clinical signs: increase work of breathing, increase oxygen requirements , increase in apnea , bradycardia and retraction.

• Laboratory: arterial blood gases and electrolytes.

• Radiology: streaky interstitial markings, patchy atelectasis , intermingled with cystic areas and severe lung hyperinflation.

Exclusion Criteria:

• Term and post term neonates

• Neonates with congenital infections

• Neonates with major congenital anomalies