Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Clinical evidence about the effects of cannabis in the management of acute pain is rather
scarce, mostly consisting of case report-based opinions on adverse events during or after
general anesthesia after smoking cannabis, experimental pain trials in healthy volunteers,
and a few clinical trials using different drugs, dosages and routes of administration. It is
difficult to draw strong conclusions from the available evidence, that may seem sometimes
even contradictory, mainly due -the investigators believe- to the many sources of variability
in the study designs (e.g.: heterogeneity of the study samples, underpowered, unblinding,
lack of randomization, timing of the therapeutic intervention, different experimental pain
models, inclusion of different kind of surgical pain, etc.). Nevertheless, expert's opinion
after a critical review of the literature is that cannabis and cannabinoids may have a
beneficial role in the management of acute pain, at least for a selected group of patients
and through an appropriate therapeutic intervention.
Cannabis oil seem to be most suitable to our investigation. The co-administration of
tetrahydrocannabinol (THC) with cannabidiol (CBD) may translate into additional therapeutic
benefits with an attenuation of adverse effects. And will help treat acute radicular back
pain