Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Chlorogenic acid has demonstrated promising effects in the treatment of glycemic control, obesity, dyslipidemia, insulin secretion, among others. The above mentioned findings show that Chlorogenic acid has an excellent potential for the control of glucose as well as insulin secretion and insulin sensitivity.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Guadalajara
• Treatments: Insulin; Insulin, Globin Zinc; Magnesium Oxide

Criteria

Inclusion Criteria:

• BMI: 30.0-34.99 kg / m2.

• Diagnosis of IGT (OGTT Values between 140mg / dl and 199mg / dl.

• Written informed consent.

• Body weight stable over the last 3 months.

• Women in follicular phase of the menstrual cycle (days 3 to 8 of the cycle) at the time of laboratory tests.

• Women who are not contemplated get pregnant within the next 6 months.

Exclusion Criteria:

• Women pregnant or breastfeeding.

• Physical or mental disability that makes it impossible to perform the intervention.

• Diagnosis of Hypertension or heart failure.

• Smokers.

• Untreated thyroid disease.

• Consumption of oral agents or other medications or supplements with proven properties that modify the behavior of glucose and lipids (oral hypoglycemic agents, insulin, lipid-lowering).

• Diagnosis of liver disease or elevation twice of the upper normal value of liver enzymes.

• Diagnosis of renal disease or creatinine > 1.5 mg / dl.

• Diagnosis of Type 2 Diabetes Mellitus (T2DM) Fasting glucose ≥ 126 mg / dL and/or OGTT ≥ 200 mg / dL and/or A1C ≥ 6.5%.

• Total Cholesterol ≥ 280 mg/dL.

• Triglycerids ≥ 300 mg/dL.

• Known allergy to calcined magnesia or Chorogenic acid.