Effect of Citalopram on Reflux Episodes in Healthy Volunteers

• Status: Completed
• Trial end date: 2017-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Citalopram is sometimes used in the treatment for gastro-esophageal reflux disease, however, there are no empirical data to support this. The investigators would like to know if citalopram has an effect on the lower esophageal sphincter pressure, transient lower esophageal sphincter relaxations and reflux episodes. The investigators will investigate this by performing high resolution impedance manometry in healthy volunteers before and after a solid meal. This will be compared to placebo, in a cross-over, randomized, double-blind condition.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• between 18 and 65 years

Exclusion Criteria:

• history of upper GI symptoms

• history of upper GI surgery

• psychological disorders

• any drug history

• use of medication altering GI motility

• nursing and pregnant woman