Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery
Status:
Recruiting
Trial end date:
2026-12-30
Target enrollment:
Participant gender:
Summary
All patients will be completed collection of demographic data, clinical data, and be observed
for inflammatory organ damage, oxygenation index or SpO2/ FIO2, WBC, NEU, interleukin-1β,
interleukin-6, interleukin-8 (IL-1β/6/8), tumor necrosis factor-α (TNF-α), C-reactive protein
(CRP), procalcitonin (PCT), myoglobin (Myo), creatine kinase-MB (CK-MB), high-sensitivity
cardiac troponin T (hs-cTnT), neutrophil elastase (NE), myeloperoxidase (MPO), APACHE II
score, alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin, Murray lung
injury score, serum creatinine, eGFR, mechanical ventilation time, ICU length of stay,
drug-related gastrointestinal reactions, and 30-day and 90-day all-cause mortality, among
other indicators.
Phase:
Phase 3
Details
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Collaborators:
First Affiliated Hospital of Harbin Medical University First Affiliated Hospital of Zhejiang University Jinan Central Hospital Renji Hospital Affiliated to The Shanghai Jiao Tong University Medical School The First People's Hospital of Changzhou Xinhua hospital of ILi in Kazakhstan automomous district Yangzhou University