Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery
Status:
Completed
Trial end date:
2011-05-31
Target enrollment:
Participant gender:
Summary
Patients over 70 years of age, scheduled for joint replacement surgery will be randomized to
tramacet/ naloxone plus morphine PCA or to morphine PCA to assess quality of analgesia in the
postoperative period.
The primary objective is to determine opioid use during combined use of oral tramacet and
naloxone infusion perioperatively in elderly patients (70 yrs and older) having elective
knee/ hip arthroplasty under spinal anesthesia.
Secondary objectives are to determine the incidence VAS scores ≥4 and adverse effects such as
nausea, vomiting, sedation, respiratory depression, pruritus, confusion, and time of
independent mobilization.
Hypothesis: Perioperative naloxone infusion and tramacet provides adequate analgesia in
elderly patients undergoing total knee/hip arthroplasty and is associated with 80% reduction
in opioid use and reduced opioid-induced side effects.