Effect of Cytokines on Growth of Children With Chronic Kidney Failure

• Status: Suspended
• Trial end date: 2003-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Children with chronic kidney failure often do not grow well. This study examines the possible causes of growth failure in these children and the response to recombinant human growth hormone. The growth hormone-insulin-like growth factor axis will be studied in relation to biochemical and immunological parameters as well as body compositional changes pre- and post recombinant human growth hormone therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Collaborator: Genentech, Inc.
• Treatments: Hormones

Criteria

Inclusion Criteria:

• Current height < 2SD (or < 3rd percentile) for chronological age

• Chronic renal failure (estimated creatinine clearance <75 mL/min/1.73m2) or ESRD (as defined by receiving maintenance HD or PD)

• Age < 21 years and /or growth potential demonstrable by bone age

Exclusion Criteria:

• Unable or unwilling to adhere to the protocol

• Additional diagnoses that could impair responsiveness to GH, e.g. dwarfism syndromes, significant extra-renal organ disease, e.g. chronic liver disease, or chronic corticosteroid therapy