Effect of DHEA on Patients With Poor Ovarian Responds

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the effect of DHEA for treatment of subfertile patients with poor ovarian reserve and post-treatment evaluation of IVF outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Affiliated Hospital of Inner Mongolia Medical University
• Collaborators: First Affiliated Hospital, Sun Yat-Sen University; Renmin Hospital of Wuhan University
• Treatments: Dehydroepiandrosterone

Criteria

Inclusion Criteria:

• Indicated for IVF treatment according to our standard department protocol

• Age < 42

• Regular menstrual cycles (21-35 days)

Poor ovarian responders are defined according to the Bologna criteria fulfilling 2 out of 3 of the following:

• Advanced maternal age (≥40) or any other genetic or acquired risk factor for POR

• Previous poor ovarian response (POR) (≤3 oocytes with a conventional stimulation protocol using at least 150IU gonadotrophins per day)

• Abnormal ovarian reserve test (i.e. AFC < 5-7 or AMH < 0.5-1.1ng/ml). Alternatively, two episodes of POR after maximal stimulation are sufficient to define a patient as poor responder in the absence of advanced maternal age or abnormal ORT.

Exclusion Criteria:

• Previous chemotherapy or pelvic irradiation

• Polycystic ovarian syndrome or polycystic ovaries

• On hormonal supplementation for any indication at the time of recruitment (e.g. estrogen, testosterone or DHEA)