Overview

Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.

Status:
Completed

Trial end date:
2016-04-01

Target enrollment:
0

Participant gender:
All

Summary

The objective of this study is to compare the value of deep neuromuscular block (NMB) (using rocuronium) in laparoscopy versus high dose opioids (using remifentanil) or 1 minimum alveolar concentration (MAC) inhalation (using sevoflurane) for the surgeon. The study hypothesis is that laparoscopic workspace is larger when using rocuronium versus opioids or inhalation. Laparoscopic workspace is measured as the abdominal compliance and the pressure at volume zero (PV0) using the abdominal pressure volume relation. Three points allow to calculate the abdominal compliance and the pressure at zero volume (PV0).

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

AZ Sint-Jan AV

Treatments:

Remifentanil
Rocuronium
Sevoflurane

Criteria

Inclusion Criteria:

1. Laparoscopic bariatric surgery in a patient older than 18 years of age without previous
laparotomy. Examples of laparoscopic bariatric procedures are gastric band, sleeve
gastrectomy, gastric bypass, gastric bypass after lap band, and revision of a gastric
bypass

Exclusion Criteria:

1. Allergies or contraindications to the use of one or more of the following drugs:
propofol, rocuronium, sugammadex, remifentanyl, or sevoflurane

2. History of a laparotomy

3. Emergency laparoscopy