Effect of Deep Versus Moderate Neuromuscular Block During Sevoflurane Anesthesia on Intraoperative Surgical Conditions.

• Status: Completed
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

A deep neuromuscular block (NMB) is often associated with improved surgical conditions especially in laparoscopic surgery. We previously showed that deep NMB is superior to a moderate NMB under propofol anesthesia. However, this may not apply to sevoflurane anesthesia and sevoflurane by itself produces some degree of muscle relaxation. We therefore plan to investigate the effect of deep NMB on surgical conditions under sevoflurane anesthesia maintenance.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Leiden University Medical Center
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Rocuronium; Sevoflurane

Criteria

Inclusion Criteria:

• Patients diagnosed with renal or prostatic disease who are will undergo an elective laparoscopic renal surgical procedure or laparoscopic prostatectomy;

• American Society of Anesthesiologists (ASA) class I-III

• > 18 years of age;

• Ability to give oral and written informed consent.

Exclusion Criteria:

• Known or suspected neuromuscular disorders impairing neuromuscular function;

• Allergies to muscle relaxants, anesthetics or narcotics;

• A (family) history of malignant hyperthermia;

• Women who are or may be pregnant or are currently breast feeding;

• Renal insufficiency, as defined by glomerular filtration rate < 30 ml/h creatinine.

• Previous retroperitoneal surgery at the site of the current surgery.

• Body mass index > 35 kg/m2