Effect of Desmopressin on the Nocturnal Micturition Frequency in Patients With Parkinson Disease

• Status: Terminated
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study will be conducted to study the effect of Desmopressin on the nocturnal micturition frequency in patients with idiopathic Parkinson syndrome.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johannes Gutenberg University Mainz
• Treatments: Deamino Arginine Vasopressin

Criteria

Inclusion Criteria:

• Male patients with idiopathic Parkinson Syndrome

• 18 to 85 years

• Nocturnal Pollakisuria > 2 mictions /night (documented in Screening phase )

• Na+ i.S > 135 mmol/l

• Patient is able to understand all aspects and individual consequences of the clinical trial

• An informed consent signed and dated by the patient is available prior to any study specific treatment

• The study is consistent with the patients´ request for an appropriate treatment

Exclusion Criteria:

• Intake of the following concomitant medication: Carbamazepin, Oxcarbazepine, diuretics (Furosemide, Torasemide), non steroidal antiphlogistics, Loperamide, antidiuretic hormone analoga (besides study medication), drugs for treatment of bladder disfunction, in particular anticholinergics

• Central Diabetes insipidus

• Known heart insufficiency (NYHA Stad. III und IV)

• clinical relevant kidney insufficiency

• Habitual and psychogenic Polydipsia

• Hypersensitivity or allergy against the trial medication or any other ingredient of the trial medication

• Participation in another clinical trial during or within 6 months prior to this clinical trial

• Medical or psychological condition, which might endanger the proper conduction of the clinical trial

• Known drug or alcohol abuse