Effect of Dexamethasone on Postoperative Inflammatory Factors

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Dexamethasone; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Adult patients ≥65years of age

• American Society of Anesthesiologists (ASA) physical status 2-4

• Elective or expedited non-cardiac surgery of at least 2 hours dura- tion under general anaesthesia

• Requiring a hospital stay of at least one postoperative night

• A surgical skin incision >5 cm in length or multiple incisions with a total incision length of >5 cm

Exclusion Criteria:·

• Poorly controlled diabetes (HbA1c>9.0%)

• Endovascular procedure with a small (<5 cm length) skin incision Ophthalmic surgery

• Planned dexamethasone (or other corticosteroid) therapy (eg, history of intractable PONV, maxillofacial surgery, intracranial neurosurgery)

• Recent (<2 weeks since end of treatment) infective episode requir- ing treatment with antibiotics

• Chronic antibiotic therapy (eg, for bronchiectasis, cystic fibrosis etc)