Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
Status:
NOT_YET_RECRUITING
Trial end date:
2026-05-03
Target enrollment:
Participant gender:
Summary
Acute kidney injury (AKI) is a frequent and serious complication after ascending aortic surgeries requiring cardiopulmonary bypass (CPB). Dexmedetomidine, a selective -2 adrenoreceptor agonist, may reduce AKI because of its sympatholytic and anti-inflammatory effects against ischaemia reperfusion injury. We investigate the effect of dexmedetomidine administration on AKI after ascending aortic surgeries requiring CPB in a placebo-controlled randomised controlled trial.