Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

• Status: Completed
• Trial end date: 2017-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• American Society Anesthesiologists classification I-III

Exclusion Criteria:

• use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree