Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia

• Status: Unknown status
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The study try to illustrate the possible mechanisms of tending to induce airway spasms and the impact of dexmedetomidine on inflammatory reaction in general anesthesia patients with asthma，by detecting the differences of plasma inflammatory factor interleukin(IL)-4, IL-5, IL-13, IL-17, IL-33, MBP and immunoglobulin E(IgE) levels between asthma patients and non-asthma patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University
• Treatments: Anesthetics; Dexmedetomidine

Criteria

Inclusion Criteria:

• Obtain informed consent

• Elective general anesthesia surgery, surgery time 1 ~ 3 hours.

• 20 patients with a history of asthma.

• 60 patients with no history of asthma.

• American Society of Anesthesiologists (ASA)classification:class I~II.

• Aged between 18 and 65 years old.

Exclusion Criteria:

• SBP≥180 mmHg or <90 mmHg, DBP≥110 mmHg or <60 mmHg.

• Serious heart, brain, liver, kidney, lung, endocrine diseases or serious infections.

• Hematopoietic dysfunction or bleeding tendency and hemorrhagic disease.

• A neuromuscular system disease.

• Airway and lung surgery.

• Predict possible or happened difficult airway.

• Immune function defect.

• Sure/suspected abuse of narcotic analgesics or drugs or alcohol dependence.

• The test drug allergy or have other contraindications in patients.

• Childbearing age women not to take appropriate contraception, pregnancy or lactation.

• Participated in other clinical drug research in the last 30 days.