Effect of Dexmedetomidine on Microcirculation in Patients Undergoing Extracorporeal Shock Wave Lithotripsy
Status:
Withdrawn
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Dexmedetomidine administration for minor procedure, such as extracorporeal shock wave
lithotripsy, provides good quality of sedation and analgesia. Dexmedetomidine is a highly
selective α2-adrenergic receptor agonist which causes sedative effects and reduces opioid
requirements in the perioperative period. Extracorporeal shock wave lithotripsy may cause
pain and result in tachycardia and vasoconstriction-related hypertension. Surgical or
procedural stress may induce inflammation and it may cause further microthrombosis. Both
vasoconstriction and microthrombosis will alter the microcirculatory status. Dysfunction of
microcirculation may impair tissue perfusion and result in organ dysfunction. Dexmedetomidine
may induce vasodilation by slow intravenous infusion for sedation. Dexmedetomidine may also
reduce inflammation. After reviewing the literature, the investigators found that the effect
of dexmedetomidine on microcirculation was not well investigated. By application of the
non-invasive technique of sidestream dark field imaging, the investigators can investigate
the vessel density, percentage of perfused vessels, and microvascular flow index on
sublingual vessels.
The goal of this study is to identify the effect of dexmedetomidine on sublingual
microcirculation in patient undergoing extracorporeal shock wave lithotripsy.